| Product name: | Human ACE2 antigen |
|---|---|
| Synonym: | Human Angiotensin-converting Enzyme 2 Antigen, Human ACE2 recombinant protein,Human ACE2 protein,Human Angiotensin-converting Enzyme 2recombinant protein, Human Angiotensin-converting Enzyme 2 protein |
| Product Type: | Recombinant protein antigen |
| Product Category: | Infectious Diseases |
| Catalog: | AG10010 |
| Qty/Pack Size: | 100ug, 1mg |
| Format: | Affinity Purified Recombinant Antigen (His-tag). |
| Source: | Human |
| Express Host: | Hek293 Cells |
| Purity: | >95% |
| Supplied In: | 10 mM Phosphate Buffer, 150 mM Sodium Chloride, pH 7.4 |
| Applications: | ELISA, Lateral Flow, CMIA |
| Storage: |
Short Term (≤ 2 weeks): 2-8°C. Long Term: -20°C. Avoid repeated freezing and thawing.
Recombinant proteins are provided as frozen liquid which are shipped with dry ice.
Bulk packages canbeprovided as lyophilized powder which shipped with blue ice. |
| Construction: | A DNA sequence encoding the Human ACE2 Protein was expressed with His-tag in C terminus. |
| Molecular Mass: | The protein of Human ACE2 consists of 731 amino acids. |
| Biological Activity: | Affinity constant (KD): 9.193×10 -9M, Association rate constant (ka): 3.288×10 6/Ms, Dissociation rateconstant(kd): 3.023×10 -2/s, Measured binding affinity with ACE2-His (UDP9005-2) by Biacore T200. |
| Endotoxin | N/A |
| Gene sequence: | NM_001371415.1 , Homo sapiens angiotensin converting enzyme 2 (ACE2), transcript variant 1, mRNA |
| Protein sequence: | NP_001358344, angiotensin-converting enzyme 2 isoform 1 precursor [Homo sapiens] |
| Discription: |
Angiotensin-converting enzyme 2 (ACE2), a first homolog of ACE, regulates the renin angiotensin system(RAS) by counterbalancing ACE activity. Accumulating evidence in recent years has demonstrated a physiological and pathological role of ACE2 in the cardiovascular, renal and respiratory systems. ACE2alsohas an important role in blood pressure control. In the acute respiratory distress syndrome (ARDS), ACE, AngII, and AT1R promote the disease pathogenesis, whereas ACE2 and the AT2R protect from ARDS. |
| Sequence: |
QSTIEEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEEN
VQNMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQ ALQQNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNPQ ECLLLEPGLNEIMANSLDYNERLWAWESWRSEVGKQLRPL YEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYS RGQLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAYPSYISPIGC LPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQA WDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGNVQ KAVCHPTAWDLGKGDFRILMCTKVTMDDFLTAHHEMGHIQ YDMAYAAQPFLLRNGANEGFHEAVGEIMSLSAATPKHLKSI
GLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWM
VFKGEIPKDQWMKKWWEMKREIVGVVEPVPHDETYCDPA SLFHVSNDYSFIRYYTRTLYQFQFQEALCQAAKHEGPLHKC DISNSTEAGQKLFNMLRLGKSEPWTLALENVVGAKNMNVR PLLNYFEPLFTWLKDQNKNSFVGWSTDWSPYADQSIKVRIS LKSALGDKAYEWNDNEMYLFRSSVAYAMRQYFLKVKNQMIL FGEEDVRVANLKPRISFNFFVTAPKNVSDIIPRTEVEKAIRMS RSRINDAFRLNDNSLEFLGIQPTLGPPNQPPVSHHHHHHHH |
| SDS Page: |
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| Note: | This product is intended for research and manufacturing uses only. It is not a diagnostic device. The user assumes all responsibility for care, custody and control of the material, including its disposal, in accordance with all regulations. |
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Human Angiotensin-converting Enzyme 2 Product Infomation
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